Wei Wu

Dr. Wu studies at the Institute of Biochemistry and Cell Biology, Shanghai Branch of the Chinese Academy of Sciences, her main research direction was the signaling mechanism of T cells, focusing on the activation mechanism of the T cell immune receptor TCR from the perspectives of signal receptors and lipid molecules, as well as the design and modification of CAR-T cells. By establishing a quantitative mass spectrometry system, it was discovered that TCR is a signal self-regulatory receptor that includes both activating and inhibitory motifs. The novel E28Z CAR-T cells designed based on this theoretical foundation have shown strong anti-tumor activity in both hematological and solid tumor models. The research findings were published in CELL and were selected as one of the "Top Ten Advances in Chinese Life Sciences" for 2020 and one of the "Important Medical Progress" in China for 2020. In addition, she wrote a review article on the regulation of T cell signaling by lipid molecules on the cell membrane, which was published in Nature Reviews Immunology. She has a systematic understanding of the molecular mechanisms by which lipid molecules regulate T cells, which can lay the foundation for future research.